KMID : 0882420080750020202
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Korean Journal of Medicine 2008 Volume.75 No. 2 p.202 ~ p.209
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The association between smoking and clinical manifestations in patients with Behcet¡¯s disease
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Lee Shin-Seok
Choe Jung-Yoon Park Sung-Hoon Kim Seong-Gyu Choi Chan-Bum Lee Eun-Kyoung
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Abstract
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Background: There is controversy related to the role of smoking in affecting the clinical features of patients with
Behcet¡¯s disease (BD). The aim of this study was to investigate the effect of smoking on clinical manifestations in Korean
BD patients.
Methods: We enrolled 131 patients with BD who fulfilled the International Study Group (ISG) criteria of 1990. The
disease-related clinical features of BD¡ªoral ulcers, genital ulcers, ocular lesions, arthritis, vascular lesions, gastrointestinal lesions¡ªand central nerve lesions, smoking history, disease duration, and the presence of HLA-B51 were retrospectively assessed through medical record reviews and patient interviews. Statistical analysis was performed using Chi-square,Fisher¡¯s exact, or student t-test, if appropriate.
Results: The frequencies of vascular and gastrointestinal lesions in smokers were significantly increased compared to those in non-smokers (p=0.040, OR=3.341, 95% CI 1.083-10.305; p=0.012, OR=3.878, 95% CI 1.379-10.906, respectively). Male smokers developed vascular lesions more frequently compared to female smokers, male non-smokers, and female non-smokers (p=0.025, OR=3.896, 95% CI 1.245-12.196). Moreover, smoking, male sex, and positive HLA-B51 may be risk factors for the development of gastrointestinal lesions in BD. Venous lesions were more frequently found in male smokers compared with other patients (p=0.038).
Conclusion: Smoking may be associated with the development of vascular and gastrointestinal lesions in Korean BD patients. A large population prospective assessment of the clinical effect of smoking on BD is needed. (Korean J Med
75:202-209, 2008)
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KEYWORD
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Behcet¡¯s disease, Smoking, Male, HLA-B51
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